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Combination of buprenorphine and naloxone for Opioid Addiction Treatment

May 12, 2010 · Posted in Buprenorphine 

Buprenorphine is effective in drug substitution therapy. Now there are new formulations in combination with naloxone.

Oral drug substitution therapy with buprenorphine is one way to try to remove drug users from dependence. A study published in the journal The Lancet states with drug substitution therapy opiates, buprenorphine, heroin users are able to make the stay “clean” for three times longer compared to people taking placebo. In addition the number of participants who completed the study without relapse four times more on buprenorphine recipients.

In development research, producing Suboxone therapy used in opioid dependence. Suboxone is the replacement of the previous drug, Subutex, which is withdrawn from the market. Just as Subutex, Suboxone has a content of buprenorphine and naloxone (Narcan). In the case of a heroin overdose, naloxone is a powerful substance that can be used to directly fight against opiates (antagonists). Naloxone can work effectively if injected into the blood.

If Suboxone is injected to the person who was an overdose of heroin, buprenorphine effect opposed by naloxone. With such conditions, the effects of buprenorphine will be lost completely. Naloxone does not work when used orally but Suboxone remain effective when used properly, with detained under the tongue.

The decision to replace Subutex to Suboxone is taken as more evidence is obtained about the abuse of Subutex. Many people formulate Subutex to injection dosage pulverize way Subutex tablets and mix it with water. Subutex Though not soluble in water. Subutex and water mixture is then injected into the body.

Use in this manner are at risk. One risk is the possibility of transmission of HIV / AIDS through shared needle use. There was also a possible risk of problems appear in the bloodstream. This condition occurs even more vulnerable if the powder is not made very smooth. In contrast to the Suboxone, because Suboxone no effect when injected, and the replacement of Subutex to Suboxone will help prevent transmission of HIV and other health problems caused by injections.

Suboxone is used to put under the tongue until dissolved, not swallowed. At appropriate doses, Suboxone is useful to reduce the pain from the use of opioids and ensuring the compliance of patients remain in treatment by suppressing substances of opoid withdrawal symptoms and reduce the sense of suggestibility to opioids.

The use of Suboxone to go through the process of prescribing by doctors and can not be done by any doctor. Only physicians who had been trained and registered alone can prescribe this. In addition, a doctor must know the patient will diobatinya. Not just any patient can be given suboxone therapy. At certain stages the patient may not get the Suboxone for that needed a deeper understanding of physicians about their use.

Suboxone is not recommended for those who are allergic to buprenorphine, naloxone, or other drug components. Discontinuing the use of Suboxone should be consulted with your doctor first, because the doctor will gradually reduce the dose to avoid or minimize drug withdrawal symptoms.

Based on FDA category, Suboxone is in the category C which means that no clearly known effects on pregnancy. Use of these drugs during pregnancy can cause withdrawal symptoms drugs on newborns. So do not use this drug while pregnant or planning a pregnancy when not in therapy. Suboxone can get into breast milk and the effect is not good at caring for babies. Therefore, Suboxone should not be used while nursing.

Comments

One Response to “Combination of buprenorphine and naloxone for Opioid Addiction Treatment”

  1. Dewitt Dimock on February 2nd, 2011 12:55 pm

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